Propranolol hydrochloride
Cat. No.：YN321537
| 产品名称: | Propranolol hydrochloride |
| CAS No.: | 318-98-9 |
| Chemical Name: | 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, monohydrochloride |
| Synonyms: | 盐酸普萘洛尔 |
| 分子量: | 295.80 |
| 分子式: | C₁₆H₂₂ClNO₂ |
| SMILES: | OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Propranolol hydrochloride 是一种非选择性的β-adrenergic receptor (βAR)拮抗剂，对 β1AR 和 β2AR 具有高亲和力，Ki值分别为 1.8 nM 和 0.8 nM。Propranolol hydrochloride 抑制 [3H]-DHA 与大鼠脑膜制剂的结合，IC50为 12 nM。Propranolol hydrochloride 可以用于高血压，嗜铬细胞瘤，心肌梗塞，心律不齐，心绞痛和肥大心肌病的相关研究。 |
| IC50和靶点: | |
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Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)
Fitzgerald, J.D., and O'Donnell, S.R.A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogsBrit. J. Pharmacol.45(2),207-217(1972)
Basil, B., Jordan, R., Loveless, A.H., et al.A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practololBr. J. Pharmacol.50(3),323-333(1974)
Costain, D.W., and Green, A.R.β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamineBr. J. Pharmacol.64(2),193-200(1978)
