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(S)-(-)-Propranolol hydrochloride

Cat. No.:YN321538

  • CAS No. :4199-10-4

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    • 产品名称: (S)-(-)-Propranolol hydrochloride
      CAS No.: 4199-10-4
      Chemical Name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2S-propanol, monohydrochloride
      Synonyms:Hemangeol, Inderal
      分子量:295.80
      分子式:C₁₆H₂₂ClNO₂
      SMILES:O[C@H](COC1=C2C=CC=CC2=CC=C1)CNC(C)C.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: (S)-(-)-Propranolol hydrochloride 是一种肾上腺素能受体 (β-adrenergic receptor) 拮抗剂,针对 β1,β2,和β3的 log Kd值分别为 -8.16,-9.08 和 -6.93。(S)-(-)-Propranolol hydrochloride 可以用于高血压,嗜铬细胞瘤,心肌梗塞,心律不齐,心绞痛和肥大心肌病的相关研究。
      IC50和靶点:
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    • Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)

      Mehvar, R., and Brocks, D.R.Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humansJ. Pharm. Pharm. Sci.4(2),185-200(2001)

      Costain, D.W., and Green, A.R.β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamineBr. J. Pharmacol.64(2),193-200(1978)

      Gerber, J.G., Freed, C.R., and Nies, A.S.Antihypertensive pharmacologyWest. J. Med.132(5),430-439(1980)

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