Nicergoline
Cat. No.：YN321561
CAS No. ：27848-84-6
| 产品名称: | Nicergoline |
| CAS No.: | 27848-84-6 |
| Chemical Name: | (8β)-10-methoxy-1,6-dimethyl-ergoline-8-methanol, 8-(5-bromo-3-pyridinecarboxylate) |
| Synonyms: | 尼麦角林 |
| 分子量: | 484.39 |
| 分子式: | C₂₄H₂₆BrN₃O₃ |
| SMILES: | CO[C@@]([C@@]1([H])C2)(C[C@@H](COC(C3=CN=CC(Br)=C3)=O)CN1C)C4=C5C2=CN(C)C5=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nicergoline 溴烟碱酸的麦角林衍生物，是一种有效，选择性和具有口服活性的α1A-肾上腺素能受体拮抗剂。Nicergoline 具有血管舒张作用。Nicergoline 可以改善阿尔茨海默症小鼠的认知功能。 |
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Alvarez-Guerra, M., Bertholom, N., and Garay, R.P.Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha1A‐adrenoceptor subtype in the ratFundam. Clin. Pharmacol.13(1),50-58(1999)
Asai, S., Zhao, H., Yamashita, A., et al.Nicergoline enhances glutamate re-uptake and protects against brain damage in rat global brain ischemiaEur. J. Pharmacol.383(3),267-274(1999)
Kim, S.-Y., Choi, J.-S., and Joo, C.-K.Effects of nicergoline on corneal epithelial wound healing in rat eyesInvest. Ophthalmol. Vis. Sci.50(2),621-625(2009)
