Celiprolol hydrochloride
Cat. No.：YN321634
| 产品名称: | Celiprolol hydrochloride |
| CAS No.: | 57470-78-7 |
| Chemical Name: | N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-urea, monohydrochloride |
| Synonyms: | Selectrol,Selecor,盐酸塞利洛尔 |
| 分子量: | 415.95 |
| 分子式: | C₂₀H₃₄ClN₃O₄ |
| SMILES: | O=C(NC1=CC=C(OCC(O)CNC(C)(C)C)C(C(C)=O)=C1)N(CC)CC.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Celiprolol hydrochloride 是一种有效的、选择性和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，因此它是一种选择性肾上腺素受体调节剂 (SAM)。Celiprolol hydrochloride 具有降压和抗心绞痛的活性。 |
| IC50和靶点: | [{name:"β adrenergic receptor:0.14-8.3 μM (Ki)"}] |
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Hoffman, D.L.Mitochondria and cellular homeostatis: Beyond ATP synthesisMitochondrial Health 2014,1-2(2014)
Chen, X., Minatoguchi, S., Arai, M., et al.Celiprolol, a selective β1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarctionCirc. J.71(4),574-579(2007)
Liao, Y., Asakura, M., Takashima, S., et al.Celiprolol, a vasodilatory β-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in miceCirculation110(6),692-699(2004)
