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Efaroxan hydrochloride

Cat. No.:YN321654

  • CAS No. :89197-00-2

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    • 产品名称: Efaroxan hydrochloride
      CAS No.: 89197-00-2
      Chemical Name: 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole, monohydrochloride
      Synonyms:Efaroxan HCl; RX 821037A; RX821037A; RX-821037A; EU-0100521; EU0100521; EU 0100521;
      分子量:252.74
      分子式:C₁₃H₁₇ClN₂O
      SMILES:CCC1(C2=NCCN2)OC3=CC=CC=C3C1.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Efaroxan hydrochloride 是一种有效的选择性性的 α2 肾上腺素受体 (α2-adrenoceptor) 拮抗剂,具有抗糖尿病的活性。Efaroxan hydrochloride 是一种选择性的 I1 咪唑啉受体 (I1-Imidazoline receptor) 的拮抗剂,可用于心血管疾病的研究。
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    • Eglen, R.M., Hudson, A.L., Kendall, D.A., et al.'Seeing through a glass darkly': Casting light on imidazoline 'I' sitesTrends Pharamacol. Sci.19(9),381-390(1998)

      Cooper, E.J., Hudson, A.L., Parker, C.A., et al.Effects of the β-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of LangerhansEur. J. Pharmacol.482(1-3),189-196(2003)

      Olmos, G., Kulkarni, R.N., Munirul, H., et al.Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptorsEur. J. Pharmacol.262(1-2),41-48(1994)

      Mayer, G., and Taberner, P.V.Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouseEur. J. Pharmacol.454(1),95-102(2002)

      Saster-Coll, A., Esteban, S., and Garcia-Sevilla, J.A.Effects of imidazoline receptor ligands on monoamine synthesis in the rat brain in vivoNaunyn Schmiedebergs Arch. Pharmacol.360(1),50-62(1999)

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