Semagacestat
Cat. No.：YN380002
CAS No. ：425386-60-3
| 产品名称: | Semagacestat |
| CAS No.: | 425386-60-3 |
| Chemical Name: | (2S)-2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide |
| Synonyms: | LY450139 |
| 分子量: | 361.44 |
| 分子式: | C₁₉H₂₇N₃O₄ |
| SMILES: | O=C([C@H]1NC([C@@H](NC([C@H](C(C)C)O)=O)C)=O)N(CCC2=C1C=CC=C2)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Semagacestat 是一种γ-secretase抑制剂，抑制β-amyloid(Aβ42)，Aβ38和Aβ40，IC50分别为 10.9，12 和 12.1 nM。也抑制Notch，IC50为 14.1 nM。 |
| IC50和靶点: | |
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Lanz, T.A., Karmilowicz, M.J., Wood, K.M., et al.Concentration-dependent modulation of amyloid-β in vivo and in vitro using the γ-secretase inhibitor, LY-450139J. Pharmacol. Exp. Ther.319(2),924-933(2006)
Mitani, Y., Yarimizu, J., Saita, K., et al.Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic miceJ. Neurosci.32(6),2037-2050(2012)
Doody, R.S., Raman, R., Farlow, M., et al.A phase 3 trial of semagacestat for treatment of Alzheimer's diseaseN. Engl. J. Med.369(4),341-350(2013)
