LX2343
Cat. No.：YN380045
CAS No. ：333745-53-2
| 产品名称: | LX2343 |
| CAS No.: | 333745-53-2 |
| Chemical Name: | N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-acetamide |
| Synonyms: | LX2343 |
| 分子量: | 474.91 |
| 分子式: | C₂₂H₁₉ClN₂O₆S |
| SMILES: | O=C(NC1=CC=C(OCO2)C2=C1)CN(C3=CC(Cl)=CC=C3OC)S(=O)(C4=CC=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LX2343 是一种BACE1酶抑制剂，IC50值为 11.43±0.36 μM。LX2343 是一种非 ATP 竞争性的PI3K抑制剂，IC50为 15.99±3.23 μM。LX2343 刺激自噬促进Aβ清除。 |
| IC50和靶点: | [{name:"BACE1:11.43 μM (IC50)"},{name: "PI3K:15.99 μM (IC50)'}, 'Aβ', 'Autophagy'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Guo, X.D., Sun, G.L., Zhou, T.T., et al.Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearanceActa Pharmacol. Sin.37(10),1281-1297(2016)
