FPS-ZM1
Cat. No.：YN380135
CAS No. ：945714-67-0
| 产品名称: | FPS-ZM1 |
| CAS No.: | 945714-67-0 |
| Chemical Name: | 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide |
| Synonyms: | N-benzyl-4-chloro-N-cyclohexylbenzamide;FPS-ZM1;FPS ZM1;4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide;BCP16845;s8185;BDBM50249567;N-Benzyl-N-cyclohexyl-4-chlorobenzamide;AK474177;FPS ZM1;FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1 |
| 分子量: | 327.85 |
| 分子式: | C₂₀H₂₂ClNO |
| SMILES: | ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FPS-ZM1是高亲和力的RAGE抑制剂，Ki值为 25 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Deane, R., Singh, I., Sagare, A.P., et al.A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer diseaseJ. Clin. Invest.122(4),1377-1392(2012)
Hong, Y., Shen, C., Yin, Q., et al.Effects of RAGE-specific inhibitor FPS-ZM1 on amyloid-β metabolism and AGEs-induced inflammation and oxidative stress in rat hippocampusNeurochem. Res.41(5),1192-1199(2016)
Kwak, T., Drews-Elger, K., Ergonul, A., et al.Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasisOncogene36(11),1559-1572(2016)
Yang, F., Wang, Z., Zhang, J.H., et al.Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhageStroke46(5),1328-1336(2015)
