Azeliragon
Cat. No.：YN380139
CAS No. ：603148-36-3
| 产品名称: | Azeliragon |
| CAS No.: | 603148-36-3 |
| Chemical Name: | 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-1-propanamine |
| Synonyms: | 阿齐瑞格; TTP488; PF-04494700 |
| 分子量: | 532.12 |
| 分子式: | C₃₂H₃₈ClN₃O₂ |
| SMILES: | ClC1=CC=C(C=C1)OC2=CC=C(C=C2)N3C(CCCC)=NC(C(C=C4)=CC=C4OCCCN(CC)CC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Azeliragon (TTP488) 是一种生物可利用的晚期糖基化终产物 (RAGE) 受体抑制剂，可缓解轻度阿尔茨海默病 (AD) 的发展。Azeliragon 还可穿过血脑屏障 (BBB)。 |
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Burstein, A.H., Sabbagh, M., Andrews, R., et al.Development of azeliragon, an oral small molecule antagonist of the receptor for advanced glycation endproducts, for the potential slowing of loss of cognition in mild Alzheimer's diseaseJ. Prev. Alzheimers Dis.5(2),149-154(2018)
