Deferoxamine mesylate
Cat. No.:YN380193
产品名称: | Deferoxamine mesylate |
CAS No.: | 138-14-7 |
Chemical Name: | N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-butanediamide, monomethanesulfonate |
Synonyms: | 甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM |
分子量: | 656.79 |
分子式: | C₂₆H₅₂N₆O₁₁S |
SMILES: | O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O.CS(=O)(O)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Deferoxamine mesylate是一种铁螯合剂,可将游离铁与稳定的复合物结合,防止其发生化学反应。 |
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Steinmetz, W.L., Glick, M.R., and Oei, T.O.Modified aca method for determination of iron chelated by deferoxamine and other chelatorsClin. Chem.26(11),1593-1597(1980)
Theriault, J.R., Felts, A.S., Bates, B.S., et al.Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathwayBioorg. Med. Chem. Lett.22(1),76-81(2012)
Jaakkola, P., Mole, D.R., Tian, Y.M., et al.Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationScience292(5516),468-472(2001)
Sandau, K.B., Zhou, J., Kietzmann, T., et al.Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxideJ. Biol. Chem.276(43),39805-39811(2001)
Neufeld, E.J.Update on iron chelators in thalassemiaHematology Am. Soc. Hematol. Educ. Program2010,451-455(2010)