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Deferoxamine mesylate

Cat. No.:YN380193

  • CAS No. :138-14-7

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    • 产品名称: Deferoxamine mesylate
      CAS No.: 138-14-7
      Chemical Name: N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-butanediamide, monomethanesulfonate
      Synonyms:甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM
      分子量:656.79
      分子式:C₂₆H₅₂N₆O₁₁S
      SMILES:O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O.CS(=O)(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Deferoxamine mesylate是一种铁螯合剂,可将游离铁与稳定的复合物结合,防止其发生化学反应。
      IC50和靶点:
      In Vitro:
      In Vivo:
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    • Steinmetz, W.L., Glick, M.R., and Oei, T.O.Modified aca method for determination of iron chelated by deferoxamine and other chelatorsClin. Chem.26(11),1593-1597(1980)

      Theriault, J.R., Felts, A.S., Bates, B.S., et al.Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathwayBioorg. Med. Chem. Lett.22(1),76-81(2012)

      Jaakkola, P., Mole, D.R., Tian, Y.M., et al.Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationScience292(5516),468-472(2001)

      Sandau, K.B., Zhou, J., Kietzmann, T., et al.Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxideJ. Biol. Chem.276(43),39805-39811(2001)

      Neufeld, E.J.Update on iron chelators in thalassemiaHematology Am. Soc. Hematol. Educ. Program2010,451-455(2010)

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