Saikosaponin C
Cat. No.：YN380225
| 产品名称: | Saikosaponin C |
| CAS No.: | 20736-08-7 |
| Chemical Name: | (3β,16β)-13,28-epoxy-16-hydroxyolean-11-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside |
| Synonyms: | 柴胡皂苷 C |
| 分子量: | 927.12 |
| 分子式: | C₄₈H₇₈O₁₇ |
| SMILES: | O[C@H]([C@@H](O)[C@]([H])(O[C@@H]1C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])C=C[C@@]45[C@@]2(C)C[C@H](O)[C@]6(CO5)[C@@]4([H])CC(C)(C)CC6)([H])[C@]3(C)CC1)O[C@@H]7CO[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H]7O[C@]9([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Saikosaponin C 是柴胡中的活性成分，在阿尔滋海默症中主要靶作用于amyloid beta和tau蛋白。Saikosaponin C 抑制 Aβ1-40 和 Aβ1-42 的释放，抑制异常 tau 蛋白的磷酸化，但对 BACE1 的活性和表达无作用。 |
| IC50和靶点: | |
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Ohuchi, K., Watanabe, M., Ozeki, T., et al.Pharmacological influence of saikosaponins on prostaglandin E2 production by peritoneal macrophagesPlanta Med.51(3),208-212(1985)
Kita, T., Hata, T., Itoh, E., et al.Analgesic and other pharmacologic actions of saiko-saponin in repeated cold stressed (SART stressed) animalsJ. Pharmacobiodyn.3(6),269-280(1980)
