Dihydroergocristine mesylate
Cat. No.：YN380251
| 产品名称: | Dihydroergocristine mesylate |
| CAS No.: | 24730-10-7 |
| Chemical Name: | 9,10α-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′α-(phenylmethyl)-ergotaman-3′,6′,18-trione, monomethanesulfonate |
| Synonyms: | DHEC mesylate |
| 分子量: | 707.84 |
| 分子式: | C₃₆H₄₅N₅O₈S |
| SMILES: | O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C(C)C)C7=O)N7[C@H]2CC8=CC=CC=C8.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dihydroergocristine mesylate (DHEC mesylate) 是γ-secretase (GSI) 的抑制剂, 可减少阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生, 与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。 |
| IC50和靶点: | |
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Lucchelli, A., Zonta, F., Grana, E., et al.Dualism in the α-adrenoceptor blocking action of dihydroergocristinePharmacol. Res. Commun.13(3),231-240(1981)
Morpurgo, C., Faini, D., and Falcone, A.Effects of phentolamine, dihydroergocristine and isoxsuprine on the blood pressure and heart rate in normotensive, hypotensive and hypertensive ratsNaunyn Schmiedebergs Arch. Pharmacol.290(4),335-346(1975)
Melena, J., Santafe, J., and Segarra, J.The effect of topical dihydroergocristine on the intraocular pressure in alpha-chymotrypsin-induced ocular hypertensive rabbitsMethods Find. Exp. Clin. Pharmacol.20(10),861-867(1998)
Boada, J.N., Feria, M., Serrano, M., et al.Inhibitory effect of dihydroergocristine, phenoxybenzamine and propranolol on the hypermotility induced by low doses of ethyl alcohol in miceArch. Farmacol. Toxicol.5(2),117-122(1979)
