AT2 receptor agonist C21
Cat. No.：YN320004
CAS No. ：477775-14-7
| 产品名称: | AT2 receptor agonist C21 |
| CAS No.: | 477775-14-7 |
| Chemical Name: | N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-carbamic acid, butyl ester |
| Synonyms: | AT2 receptor agonist C21 |
| 分子量: | 475.62 |
| 分子式: | C₂₃H₂₉N₃O₄S₂ |
| SMILES: | O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT2 receptor agonist C21 是一种类似药物的，选择性angiotensin II AT2 receptor(血管紧张素 II AT2 受体)激动剂，对 AT2 受体和 AT1 受体的Ki值分别为 0.4 nM 和 10 µM。 |
| IC50和靶点: | [{name:"AT2 Receptor:0.4 nM (Ki)"},{name: "AT1 Receptor:>10 μM (Ki)"}] |
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Wan, Y., Wallinder, C., Plouffe, B., et al.Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonistJ. Med. Chem.47(24),5995-6008(2004)
Bruce, E., Shenoy, V., Rathinasabapathy, A., et al.Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosisBr. J. Pharmacol.172(9),2219-2231(2004)
Schwengel, K., Namsolleck, P., Lucht, K., et al.Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in miceJ. Mol. Med. (Berl.)94(8),957-966(2016)
