Angiotensin (1-7)
Cat. No.：YN320589
CAS No. ：51833-78-4
| 产品名称: | Angiotensin (1-7) |
| CAS No.: | 51833-78-4 |
| Chemical Name: | 5-L-Isoleucine-1-7-angiotensin II; 1-7-Human angiotensin; 1-7-Human angiotensin 1; 1-7-Human angiotensin 2; 1-7-Human angiotensin I; 1-7-Human angiotensin II; 1-7-[Ile5]-angiotensin; 115: PN: WO2006032674 SEQID: 115 claimed sequence; 11: PN: WO0212471 SEQ |
| Synonyms: | Ang-(1-7) |
| 分子量: | 899.00 |
| 分子式: | C₄₁H₆₂N₁₂O₁₁ |
| SMILES: | O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@@]([C@@H](C)CC)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Angiotensin 1-7 (Ang-(1-7)) 是肾素-血管紧张素系统 (RAS) 的主要活性成分，由血管紧张素转换酶 2 (ACE2) 分解血管紧张素 II 产生。Angiotensin 1-7 抑制纯化的犬血管紧张素转换酶 (ACE) 活性，IC50值为 0.65 μM。Angiotensin 1-7 通过抑制血管紧张素转换酶和释放一氧化氮，可作为激肽诱导的血管舒张的局部协同调节剂。Angiotensin 1-7 阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑 |
| IC50和靶点: | |
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Verlackt, C., et al.: J Phys Chem C, 121, 5787 (2017)
