Telmisartan
Cat. No.：YN320812
CAS No. ：144701-48-4
| 产品名称: | Telmisartan |
| CAS No.: | 144701-48-4 |
| Chemical Name: | 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid |
| Synonyms: | 替米沙坦; BIBR 277 |
| 分子量: | 514.62 |
| 分子式: | C₃₃H₃₀N₄O₂ |
| SMILES: | O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(C5=NC6=CC=CC=C6N5C)=CC(C)=C4N=C3CCC)C=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Telmisartan 是一种有效的血管紧张素II 1型受体 (angiotensin II type 1 receptor) 拮抗剂，能够抑制其活性，IC50值为 9.2 nM。 |
| IC50和靶点: | |
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Frampton, J.E.Telmisartan: A review of its use in cardiovascular disease preventionDrugs71(6),651-677(2011)
Wienen, W., Hauel, N., Van Meel, J.C.A., et al.Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277Br. J. Pharmacol.110(1),245-252(1993)
Benson, S.C., Pershadsingh, H.A., Ho, C.I., et al.Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activityHypertension43(5),993-1002(2004)
McClellan, K.J., and Markham, A.TelmisartanDrugs56(6),1039-1044(1998)
Jugdutt, B.I.Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderlyClin. Interv. Aging5,403-416(2010)
Schmieder, R.E., Bakris, G., and Weir, M.R.Telmisartan in incipient and overt diabetic renal diseaseJ. Nephrol.24(3),263-273(2011)
