Azilsartan medoxomil
Cat. No.：YN320903
| 产品名称: | Azilsartan medoxomil |
| CAS No.: | 863031-21-4 |
| Chemical Name: | 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester |
| Synonyms: | 阿齐沙坦酯; TAK-491 |
| 分子量: | 568.53 |
| 分子式: | C₃₀H₂₄N₄O₈ |
| SMILES: | O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NC(ON5)=O)C=C3)=CC=C1)OCC6=C(C)OC(O6)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Azilsartan酯(TAK 491)是口服活性的1型血管紧张素II受体拮抗剂，IC50为0.62 nM。 |
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Ojima, M., Igata, H., Tanaka, M., et al.In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studiesJ. Pharmacol. Exp. Ther.336(3),801-808(2011)
French, C.J., Zaman, A.K., and Sobel, B.E.The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaquesJ. Cardiovasc. Pharmacol.58(2),143-148(2011)
Kusumoto, K., Igata, H., Ojima, M., et al.Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog modelsEur. J. Pharmacol.669(1-3),84-93(2011)
