Azilsartan
Cat. No.：YN320931
CAS No. ：147403-03-0
| 产品名称: | Azilsartan |
| CAS No.: | 147403-03-0 |
| Chemical Name: | 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid |
| Synonyms: | TAK-536 |
| 分子量: | 456.45 |
| 分子式: | C₂₅H₂₀N₄O₅ |
| SMILES: | O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C(N5)=NOC5=O)C=C3)=CC=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Azilsartan(TAK-536)是特异且高活性的血管紧张素Ⅱ1型受体拮抗剂，IC50为2.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kohara, Y., Kubo, K., Imamiya, E., et al.Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteresJ. Med. Chem.39(26),5228-5235(1996)
Ojima, M., Igata, H., Tanaka, M., et al.In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studiesJ. Pharmacol. Exp. Ther.336(3),801-808(2011)
Clas, S.-D., Sanchez, R.I., and Nofsinger, R.Chemistry-enabled drug delivery (prodrugs): Recent progress and challengesDrug Discov. Today19(1),79-87(2014)
