Losartan potassium
Cat. No.：YN321157
| 产品名称: | Losartan potassium |
| CAS No.: | 124750-99-8 |
| Chemical Name: | 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt |
| Synonyms: | 氯沙坦钾; DuP-753 potassium |
| 分子量: | 461.00 |
| 分子式: | C₂₂H₂₂ClKN₆O |
| SMILES: | OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=N[N-]N=N4)C=C2.[K+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Losartan potassium (DuP-753 potassium) 是血管紧张素 II 受体 1 型 (AT1)拮抗剂，与血管紧张素 II 与 AT1 的结合竞争，IC50为 20 nM。 |
| IC50和靶点: | |
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Ji, H., Leung, M., Zhang, Y., et al.Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartanJ. Biol. Chem.269(24),16533-16536(1994)
Núñez, A., Gómez, J., Zalba, L.R., et al.Losartan inhibits in vitro platelet activation: Comparison with candesartan and valsartanJ. Renin Angiotensin Aldosterone Syst.1(2),175-179(2000)
Ge, J., Huang, D., Liang, C., et al.Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartanAtherosclerosis177(2),263-268(2004)
Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al.Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteriesBr. J. Pharmacol.143(1),215-225(2004)
Kim, E., Hwang, S.-H., Kim, H.-K., et al.Losartan, an angiotensin II type 1 receptor antagonist, alleviates mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain by inhibiting inflammatory cytokines in the dorsal root gangliaMol. Neurobiol.56(11),7408-7419(2019)
