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Valsartan

Cat. No.:YN321180

  • CAS No. :137862-53-4

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    • 产品名称: Valsartan
      CAS No.: 137862-53-4
      Chemical Name: N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
      Synonyms:缬沙坦; CGP 48933
      分子量:435.52
      分子式:C₂₄H₂₉N₅O₃
      SMILES:CC(C)[C@@H](C(O)=O)N(C(CCCC)=O)CC1=CC=C(C2=CC=CC=C2C3=NNN=N3)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Valsarta (CGP-48933) 是血管紧张素II受体拮抗剂,有潜力用于高血压和心力衰竭的研究。
      IC50和靶点:
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    • Frampton, J.E.Telmisartan: A review of its use in cardiovascular disease preventionDrugs71(6),651-677(2011)

      Burnier, M.Angiotensin II type 1 receptor blockersCirculation103(6),904-912(2001)

      Munger, M.A.Use of angiotensin receptor blockers in cardiovascular protection: Current evidence and future directionsPT36(1),22-40(2011)

      Suematsu, Y., Miura, S., Goto, M., et al.LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic miceEur. J. Heart Fail.18(4),386-393(2016)

      Irons, B.K., Tsikouris, J.P., and Thomas, A.A.The use of angiostensin receptor blockers in the treatment of chronic hear failureJ. Cardiovasc. Pharmacol.44(6),718-724(2004)

      Schiffrin, E.L.Beyond blood pressure: The endothelium and atherosclerosis progressionAm. J. Hypertens.15(10 Pt 2),115S-122S(2002)

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