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LCZ696

Cat. No.:YN321181

  • CAS No. :936623-90-4

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: LCZ696
      CAS No.: 936623-90-4
      Chemical Name: N-(1-oxopentyl)-N-[[2’-(2H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1’-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
      Synonyms:Sacubitril/Valsartan
      分子量:957.99
      分子式:C₄₈H₆₀N₆Na₃O₁₀.₅
      SMILES:O=C(CCC(O[Na])=O)N([C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O)[H].O=C(O[Na])[C@@H](N(C(CCCC)=O)CC3=CC=C(C4=CC=CC=C4C5=NN=NN5[Na])C=C3)C(C)C.[2.5H2O]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: LCZ696 (Sacubitril/Valsartan) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成,摩尔比为 1:1,是一种首创的,口服生物可利用的双作用血管紧张素受体(ARN)抑制剂,用于研究高血压和心力衰竭。LCZ696 可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Burnier, M.Angiotensin II type 1 receptor blockersCirculation103(6),904-912(2001)

      Schiering, N., D'Arcy, A., Villard, F., et al.Structure of neprilysin in complex with the active metabolite of sacubitrilSci. Rep.6,27909(2016)

      Gu, J., Noe, A., Chandra, P., et al.Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)J. Clin. Pharmacol.50(4),401-414(2010)

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