Tranilast
Cat. No.：YN321419
| 产品名称: | Tranilast |
| CAS No.: | 53902-12-8 |
| Chemical Name: | 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-benzoic acid |
| Synonyms: | 曲尼司特; MK-341; SB 252218 |
| 分子量: | 327.33 |
| 分子式: | C₁₈H₁₇NO₅ |
| SMILES: | O=C(O)C1=CC=CC=C1NC(/C=C/C2=CC=C(OC)C(OC)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tranilast (MK-341) 是一种抗变态反应剂。抑制前列腺素 D2 产生 (PGD2，IC50=0.1 mM)。具有抗炎和免疫调节作用。Tranilast sodium 拮抗血管紧张素 II (angiotensin II) 并抑制其在血管平滑肌细胞中的生物学作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Baba, A., Tachi, M., Ejima, Y., et al.Anti-allergic drugs tranilast and ketotifen dose-dependently exert mast cell-stabilizing propertiesCell Physiol. Biochem.38(1),15-27(2016)
Ikai, K., Ujihara, M., Fujii, K., et al.Inhibitory effect of tranilast on prostaglandin D synthetaseBiochem. Pharmacol.38(16),2673-2676(1989)
Capper, E.A., Roshak, A.K., Bolognese, B.J., et al.Modulation of human monocyte activities by tranilast, SB 252218, a compund demonstrating efficacy in restenosisJ. Pharmacol. Exp. Ther.295(3),1061-1069(2000)
Koyama, S., Takagi, H., Otani, A., et al.Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cellsBr. J. Pharmacol.127(2),537-545(1999)
Koda, A., Nagai, H., Watanabe, S., et al.Inhibition of hypersensitivity reactions by a new drug, N(3’,4’-dimethoxycinnamoyl) anthranilic acid (N-5’)J. Allergy Clin. Immunol.57(5),396-407(1975)
