Candesartan D4
Cat. No.：YN321429
| 产品名称: | Candesartan D4 |
| CAS No.: | 1346604-70-3 |
| Chemical Name: | 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-benzimidazole-7-carboxylic acid |
| Synonyms: | 坎地沙坦 D4; CV-11974 D4 |
| 分子量: | 444.48 |
| 分子式: | C₂₄H₁₆D₄N₆O₃ |
| SMILES: | [2H]C1=C(CN2C(C(C(O)=O)=CC=C3)=C3N=C2OCC)C([2H])=C([2H])C(C4=CC=CC=C4C5=NNN=N5)=C1[2H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Candesartan D4 (CV-11974 D4) 是 Candesartan 的氘代物。 |
| IC50和靶点: | |
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Inada, Y., Nakane, T., and Chiba, S.Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptorsFundam. Clin. Pharmacol.16(4),317-323(2002)
Shibouta, Y., Inada, Y., Ojima, M., et al.Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)J. Pharmacol. Exp. Ther.266(1),114-120(1993)
