Amphotericin B
Cat. No.：YN250956
| 产品名称: | Amphotericin B |
| CAS No.: | 1397-89-3 |
| Chemical Name: | (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaen |
| Synonyms: | 两性霉素B |
| 分子量: | 924.08 |
| 分子式: | C₄₇H₇₃NO₁₇ |
| SMILES: | C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。 它与麦角甾醇不可逆地结合，导致膜完整性破坏并最终导致细胞死亡。 |
| IC50和靶点: | |
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Miceli, M.H., and Chandrasekar, P.Safety and efficacy of liposomal amphotericinB for the empirical therapy of invasive fungalinfections in immunocompromised patientsInfect. Drug. Resist.5,9-16(2012)
Wasan, K.M., Wasan, E.K., Gershkovich, P., et al.Highly effective oral amphotericin B formulation against murine visceral leishmaniasisJ. Infect. Dis.200,357-360(2009)
Radomski, N., Cambau, E., Moulin, L., et al.Comparison of culture methods for isolation of nontuberculous mycobacteria from surface watersAppl. Environ. Microbiol.76(11),3514-3520(2010)
Ogita, A., Fujita, K.i., and Tanaka, T.Enhancing effects on vacuole-targeting fungicidal activity of amphotericin BFront. Microbiol.3,100(2012)
