Emetine dihydrochloride hydrate
Cat. No.：YN251330
CAS No. ：7083-71-8
| 产品名称: | Emetine dihydrochloride hydrate |
| CAS No.: | 7083-71-8 |
| Chemical Name: | (2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine, dihydrochloride, hydrate |
| Synonyms: | |
| 分子量: | 571.58 |
| 分子式: | C₂₉H₄₀N₂O₄ . ₂ HCl . H₂O |
| SMILES: | CC[C@@H]1[C@H](C[C@@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C1)C[C@]4([H])C5=CC(OC)=C(OC)C=C5CCN4.[H]Cl.[H]Cl.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Emetine dihydrochloride hydrate 是从吐根根部提取的，是一种有效的抗原生动物和催吐剂。Emetine dihydrochloride hydrate 可以抑制病毒聚合酶 (viral polymerases)，并可以抑制寨卡病毒和埃博拉病毒感染。Emetine dihydrochloride hydrate 有效抑制自噬 (autophagy)，具有抗疟疾，抗菌和抗阿米巴虫作用。 |
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Burchard, G.D., and Mirelman, D.Entamoeba histolytica: Virulence potential and sensitivity to metronidazole and emetine of four isolates possessing nonpathogenic zymodemesExp. Parasitol.66(2),231-242(1988)
Miller, S.C., Huang, R., Sakamuru, S., et al.Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of actionBiochem. Pharmacol.79(9),1272-1280(2016)
Hasegawa, M., Sasaki, T., Sadakane, K., et al.Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: Involvement of 5-hydroxytryptamine receptorsJpn. J. Pharmacol.89(2),113-119(2002)
Choy, K.-T., Wong, A.-Y., Kaewpreedee, P., et al.Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitroAntiviral Res.178,104786(2020)
