Calcimycin
Cat. No.：YN251685
| 产品名称: | Calcimycin |
| CAS No.: | 52665-69-7 |
| Chemical Name: | 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl-4-benzoxazolecarboxylic acid |
| Synonyms: | A-23187; Antibiotic A-23187 |
| 分子量: | 523.62 |
| 分子式: | C₂₉H₃₇N₃O₆ |
| SMILES: | O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC=C1NC)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Calcimycin (A-23187) 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore)，如钙离子和镁离子。Calcimycin 通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。Calcimycin 抑制革兰氏阳性细菌和一些真菌的生长，还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS)，诱导细胞凋亡。 |
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Cho, S.-Y., Lee, J.-H., Bae, H.-D., et al.Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of BaxExp. Mol. Med.42(9),639-650(2010)
Kenny, E.F., Herzig, A., Krüger, R., et al.Diverse stimuli engage different neutrophil extracellular trap pathwayseLife6,e24437(2017)
