Filipin complex
Cat. No.：YN251698
| 产品名称: | Filipin complex |
| CAS No.: | 11078-21-0 |
| Chemical Name: | |
| Synonyms: | 菲律宾菌素复合体 |
| 分子量: | 654.80 |
| 分子式: | C₃₅H₅₈O₁₁ (for Filipin III) |
| SMILES: | [Filipin complex] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Filipin 在自然界中被称为 Filipin complex (Filipins I-IV)，Filipin 是一种28-元环五烯大环内酯类抗真菌抗生素，由S. filipinensis，S. avermitilis和S. miharaensis产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。Filipin III 是 Filipin 的主要成分。 |
| IC50和靶点: | |
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Shaw, P.D., Allam, A.M., and Gottlieb, D.Effect of filipin on the terminal electron transport system of Saccharomyces cerevisiaeBiochim. Biophys. Acta89(1),33-41(1964)
Kitajima, Y., Sekiya, T., and Nozawa, Y.Freeze-fracture ultrastructural alterations induced by filipin, pimaricin, nystatin and amphotericin B in the plasmia membranes of Epidermophyton, Saccharomyces and red complex-induced membrane lesionsBiochim. Biophys. Acta455(2),452-465(1976)
Miller, R.G.Mini Review. The use and abuse of filipin to localize cholesterol in membranesCell Biol. Int. Rep.8(7),519-535(1984)
Kleinschmidt, M.G., and Chough, K.S.Effect of filipin on liposomes prepared with different types of steroidsPlant Physiol.49(5),852-856(1972)
Castanho, M.A., Coutinho, A., and Prieto, M.J.Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterolJ. Biol. Chem.267(1),204-209(1992)
Sekiya, T., Takenawa, T., and Nozawa, H.Reorganization of membrane cholesterol during membrane fusion in myogenesis in vitro: A study using the filipin-cholesterol complexCell Struct. Funct.9(2),143-155(1984)
Bridgman, P.C., and Nakajima, Y.Distribution of filipin-sterol complexes on cultured muscle cells: Cell-substratum contact areas associated with acetylcholine receptor clustersJ. Cell Biol.96(2),363-372(1983)
