Budesonide
Cat. No.:YN320760
产品名称: | Budesonide |
CAS No.: | 51333-22-3 |
Chemical Name: | 16α,17-[butylidenebis(oxy)]-11β,21-dihydroxy-pregna-1,4-diene-3,20-dione |
Synonyms: | 布地奈德 |
分子量: | 430.53 |
分子式: | C₂₅H₃₄O₆ |
SMILES: | O=C(C=C[C@@]12C)C=C1CC[C@@]([C@]2([H])[C@@H](O)C[C@@]34C)([H])[C@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(CCC)O5 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Budesonide 是一种吸入型糖皮质类固醇,具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。Budesonide 可减少肺部肿瘤的大小,逆转 DNA 低度甲基化并调节基因的 mRNA 表达。Budesonide 是一种可以用于哮喘的抗炎药。 |
IC50和靶点: | |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Grossmann, C., Scholz, T., Rochel, M., et al.Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: A comparison of their glucocorticoid and mineralocorticoid propertiesEur. J. Endocrinol.151(3),397-406(2004)
Millan, D.S., Ballard, S.A., Chunn, S., et al.Design and synthesis of long acting inhaled corticosteroids for the treatment of asthmaBioorg. Med. Chem. Lett.21(19),5826-5830(2011)
Birrell, M.A., Hardaker, E., Wong, S., et al.IκB kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthmaAm. J. Respir. Crit. Care Med.172(8),962-971(2005)
Ekström, G.M.Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acidScand. J. Gastroenterol.33(2),174-179(1998)