Calphostin C
Cat. No.：YN252008
CAS No. ：121263-19-2
| 产品名称: | Calphostin C |
| CAS No.: | 121263-19-2 |
| Chemical Name: | (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic acid |
| Synonyms: | UCN-1028C |
| 分子量: | 790.8 |
| 分子式: | C44H38O14 |
| SMILES: | OC1=C(C(C(OC)=C(C[C@@H](C)OC(OC2=CC=C(O)C=C2)=O)C3=C(C(C[C@@H](C)OC(C4=CC=CC=C4)=O)=C5OC)C(C6=C(OC)C=C7O)=C7C5=O)=O)C3=C6C(OC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Calphostin C 是一种有效且特异性的蛋白激酶 C (protein kinase C) 抑制剂。Calphostin C 是一种抗肿瘤抗生素。Calphostin C 对蛋白激酶 C 的抑制作用是其他蛋白激酶的 1000 倍，其IC50为 0.05 μM。Calphostin C 在一些肿瘤细胞系中诱导细胞凋亡 (apoptosis)。Calphostin C 具有强大的细胞毒活性和抗肿瘤活性。 |
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Kobayashi, E., Ando, K., Nakano, H., et al.Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)42(10),1470-1474(1989)
Bruns, R.F., Miller, F.D., Merriman, R.L., et al.Inhibition of protein kinase C by calphostin C is light-dependentBiochem. Biophys. Res. Commun.176(1),288-293(1991)
Sciorra, V.A., Hammond, S.M., and Morris, A.J.Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-cBiochemistry40(8),2640-2646(2001)
