Cilastatin-
Cat. No.：YN252009
| 产品名称: | Cilastatin- |
| CAS No.: | 121-40-4 |
| Chemical Name: | (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione |
| Synonyms: | Terreic Acid; TA; (-)-Terreic Acid. |
| 分子量: | 154.1 |
| 分子式: | C7H6O4 |
| SMILES: | O=C(C(O)=C1C)[C@H]2[C@H](O2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Terreic acid 是一种醌环氧化物抗生素 (antibiotic)，是一种有效的Btk抑制剂。 Terreic acid 阻断PKC和Btk的 PH结构域之间的相互作用。 Terreic acid 作用于HMC-1 人肥大细胞裂解物，抑制 GST-BtkPH 与PKC结合，IC50约为 100 μM。 |
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Guo, C.J., Sun, W.W., Bruno, K.S., et al.Molecular genetic characterization of terreic acid pathway in Aspergillus terreusOrg. Lett.16(20),5250-5253(2014)
Kawakami, Y., Hartman, S.E., Kinoshita, E., et al.Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinaseProc. Natl. Acad. Sci. USA96,2227-2232(1999)
Subramanian, T., Namasivayam, K.M., and Shanmugasundaram, E.R.In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acidsToxicol. Lett.10(2-3),249-253(1982)
Han, H., Yang, Y., Olesen, S.H., et al.The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)Biochemistry49(19),4276-4282(2010)
