Miransertib hydrochloride
Cat. No.：YN252028
| 产品名称: | Miransertib hydrochloride |
| CAS No.: | 1313883-00-9 |
| Chemical Name: | |
| Synonyms: | ARQ-092 hydrochloride |
| 分子量: | 468.98 |
| 分子式: | C27H25ClN6 |
| SMILES: | C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Miransertib hydrochloride (ARQ-092 hydrochloride) 是一种有效的，具有口服活性的，选择性和变构性Akt抑制剂，对Akt1，Akt2，Akt3的IC50分别为 2.7 nM，14 nM 和 8.1 nM。Miransertib hydrochloride 还是有效的AKT1-E17K突变蛋白抑制剂，并可用于 PI3K/AKT 驱动的肿瘤和 Proteus 综合征的研究。Miransertib hydrochloride 有效抑制利什曼原虫 (Leishmani |
| IC50和靶点: | [{name:"Akt1:2.7 nM (IC50)'}, 'Leishmania', {'Akt3:8.1 nM (IC50)"},{name: "Akt2:174 nM (IC50)'}, 'Akt1 E17K mutant'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
