Clathrin-IN-1
Cat. No.：YN252032
| 产品名称: | Clathrin-IN-1 |
| CAS No.: | 1332879-52-3 |
| Chemical Name: | N-[5-[(4-bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide |
| Synonyms: | |
| 分子量: | 473.4 |
| 分子式: | C20H13BrN2O3S2 |
| SMILES: | O=C1/C(SC(NS(C2=C(C=CC=C3)C3=CC=C2)(=O)=O)=N1)=C/C4=CC=C(Br)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clathrin-IN-1 是一种选择性网格蛋白介导的内吞 (CME) 抑制剂。Clathrin-IN-1 选择性抑制两性蛋白与网格蛋白氨基末端结构域的结合，IC50值为 12 μM。Clathrin-IN-1 干扰受体介导的内吞作用，HIV的进入和突触小泡的回收。 |
| IC50和靶点: | |
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von Kleist, L., Stahlschmidt, W., Bulut, H., et al.Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibitionCell146(3),471-484(2012)
Dutta, D., Williamson, C.D., Cole, N.B., et al.Pitstop 2 is a potent inhibitor of clathrin-independent endocytosisPLoS One7(9),e45799(2012)
