Plitidepsin
Cat. No.：YN252039
| 产品名称: | Plitidepsin |
| CAS No.: | 137219-37-5 |
| Chemical Name: | N-[1-(1,2-dioxopropyl)-L-prolyl]-didemnin A |
| Synonyms: | Aplidine; PM90001 |
| 分子量: | 1110.33886 |
| 分子式: | C57H87N7O15 |
| SMILES: | O=C1N2[C@](CCC2)([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]([C@H](CC(O[C@H](C([C@@H](C(N[C@H]1CC(C)C)=O)C)=O)C(C)C)=O)O)([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H]3N(C(C(C)=O)=O)CCC3)=O)=O)C)=O)CC4=CC=C(C=C4)OC)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Plitidepsin (Aplidine) 是一种靶向eEF1A2(KD=80 nM) 的有效抗癌活性分子。Plitidepsin 有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Plitidepsin 通常用于多发性骨髓瘤和晚期癌症研究，具有 COVID-19 研究的潜力。 |
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Losada, A., Muñoz-Alonso, M.J., García, G., et al.Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsinSci. Rep.6,35100(2016)
Delgado-Calle, J., Kurihara, N., Atkinson, E.G., et al.Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclastsOncotarget10(28),2709-2721(2019)
White, K.M., Rosales, R., Yildiz, S., et al.Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1AScience371(6532),926-931(2021)
