UK-1
Cat. No.：YN252065
| 产品名称: | UK-1 |
| CAS No.: | 151271-53-3 |
| Chemical Name: | 2'-(2-hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid, methyl ester |
| Synonyms: | |
| 分子量: | 386.4 |
| 分子式: | C22H14N2O5 |
| SMILES: | OC(C=CC=C1)=C1C2=NC3=C(C=CC=C3C4=NC5=C(C=CC=C5C(OC)=O)O4)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UK-1 是链霉菌 517-02 的细胞毒性代谢产物，具有广泛的抗肿瘤活性。UK-1 还可抑制HCV复制。 |
| IC50和靶点: | |
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Ueki, M., Ueno, K., Miyadoh, S., et al.UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological propertiesJ. Antibiot. (Tokyo)46(7),1089-1094(1993)
Reynolds, M.B., DeLuca, M.R., and Kerwin, S.M.The novel Bis(benzoxazole) Cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase IIBioorg. Chem.27(4),326-337(1999)
Ward, D.N., Talley, D.C., Tavag, M., et al.UK-1 and structural analogs are potent inhibitors of hepatitis C virus replicationBioorg. Med. Chem. Lett.24(2),609-612(2014)
