bpV(phen) trihydrate
Cat. No.：YN252082
CAS No. ：171202-16-7
| 产品名称: | bpV(phen) trihydrate |
| CAS No.: | 171202-16-7 |
| Chemical Name: | (PB-7-23-111’1’3)-oxodiperoxy(1,10-phenanthroline-κN1,κN10)-vanadate(1-), potassium trihydrate |
| Synonyms: | Bisperoxovanadium(phen);bpV(phen) potassium hydrate |
| 分子量: | 404.3 |
| 分子式: | C12H8N2O5V • K+(H2O)3 |
| SMILES: | O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.O.O.O.[K+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | bpV(phen) trihydrate，一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和PTEN抑制剂，对PTEN，PTP-β和PTP-1B的IC50为 38 nM，343 nM 和 920 nM。bpV(phen) trihydrate 在体外抑制原生动物寄生虫利什曼原虫的增殖。bpV(phen) trihydrate 强烈诱导大量趋化因子和促炎性细胞因子的分泌，并激活Th1型途径 (IL-12，IFNγ)。bpV(phen) trihydrate 还可以诱导细胞凋亡 (apoptosi |
| IC50和靶点: | |
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Band, C.J., Posner, B.I., Dumas, V., et al.Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: Specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen)Mol. Endocrinol.11(13),1899-1910(1997)
