YM-53601
Cat. No.：YN252090
| 产品名称: | YM-53601 |
| CAS No.: | 182959-33-7 |
| Chemical Name: | 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride |
| Synonyms: | |
| 分子量: | 372.9 |
| 分子式: | C21H21FN2O • HCl |
| SMILES: | F/C(COC1=CC2=C(C(C=CC=C3)=C3N2)C=C1)=C4C5CCN(CC5)C\4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YM-53601 是一种角鲨烯合酶 (squalene synthase) 抑制剂，可降低体内血浆胆固醇和甘油三酯水平。YM-53601 抑制源自人肝癌细胞的角鲨烯合酶，IC50为 79 nM。可用作降脂剂。YM-53601 还是法呢基二磷酸法呢基转移酶 1 (FDFT1) 酶活性的抑制剂，可抑制HCV传播。 |
| IC50和靶点: | |
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Ugawa, T., Kakuta, H., Moritani, H., et al.YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal speciesBr. J. Pharmacol.131,63-70(2000)
Saito, K., Shirasago, Y., Suzuki, T., et al.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virusJ. Virol.89(4),2220-2232(2015)
Statt, S., Ruan, J.W., Hung, L.Y., et al.Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cellsAm. J. Respir. Cell Mol. Biol.53(5),689-702(2015)
