Baloxavir marboxil
Cat. No.：YN252099
CAS No. ：1985606-14-1
| 产品名称: | Baloxavir marboxil |
| CAS No.: | 1985606-14-1 |
| Chemical Name: | [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]-carbonic acid, methyl ester |
| Synonyms: | S-033188; RG 6152 |
| 分子量: | 571.5503464 |
| 分子式: | C27H23F2N3O7S |
| SMILES: | O=C1N(CCOC2)[C@]2([H])N([C@H]3C4=CC=C(F)C(F)=C4CSC5=CC=CC=C53)N(C=CC6=O)C1=C6OCOC(OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Baloxavir marboxil (S-033188) 是一种选择性的帽依赖性核酸内切酶 (endonuclease) 抑制剂，Baloxavir marboxil 是一种有效的抗病毒剂，具有抗甲型和乙型流感病毒 (influenza A/B) 活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Fukao, K., Ando, Y., Noshi, T., et al.Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse modelsPLoS One14(5),e0217307(2019)
Noshi, T., Kitano, M., Taniguchi, K., et al.In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunitAntiviral Res.160,109-117(2017)
