Fasudil dihydrochloride
Cat. No.：YN252103
| 产品名称: | Fasudil dihydrochloride |
| CAS No.: | 203911-27-7 |
| Chemical Name: | hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine, dihydrochloride |
| Synonyms: | HA-1077 dihydrochloride; AT-877 dihydrochloride |
| 分子量: | 364.3 |
| 分子式: | C14H17N3O2S • 2HCl |
| SMILES: | O=S(C1=CC=CC2=CN=CC=C21)(N3CCNCCC3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fasudil (HA-1077; AT877) dihydrochloride 是一种非特异性RhoA/ROCK抑制剂，并抑制蛋白激酶。Fasudil dihydrochloride 抑制ROCK1的Ki为 0.33 μM，抑制ROCK2，PKA，PKC，PKG的IC50分别为 0.158 μM 和 4.58 μM，12.30 μM，1.650 μM。Fasudil dihydrochloride 也是一种有效的 Ca2+通道拮抗剂和血管扩张剂。 |
| IC50和靶点: | [{name:"PKA:4.58 μM (IC50)"},{name: "PKC:12.3 μM (IC50)"},{name: "p160ROCK:0.33 μM (Ki)"},{name: "ROCK2:0.158 μM (IC50)"},{name: "PKG:1.65 μM (IC50)"}] |
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Oka, M., Homma, N., Taraseviciene-Stewart, L., et al.Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in ratsCirc. Res.100(6),923-929(2007)
Yin, L., Morishige, K.i., Takahashi, T., et al.Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivoMol. Cancer Ther.6(5),1517-1525(2007)
Kikuchi, Y., Yamada, M., Imakiire, T., et al.A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic ratsJ. Endocrinol.192(3),595-603(2007)
