AT-130
Cat. No.：YN252107
CAS No. ：211364-06-6
| 产品名称: | AT-130 |
| CAS No.: | 211364-06-6 |
| Chemical Name: | N-[(1E)-2-bromo-2-(2-methoxyphenyl)-1-(1-piperidinylcarbonyl)ethenyl]-4-nitro-benzamide |
| Synonyms: | |
| 分子量: | 488.3313 |
| 分子式: | C22H22BrN3O5 |
| SMILES: | Br/C(C1=C(C=CC=C1)OC)=C(NC(C2=CC=C(C=C2)[N+]([O-])=O)=O)\C(N3CCCCC3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT-130 是一种苯基丙烯酰胺衍生物，是一种有效的乙型肝炎病毒 (HBV) 复制的非核苷抑制剂。AT-130 抑制病毒 DNA 的合成，EC50为 0.13 μM。AT-130 可以抑制野生型和突变型HBV。AT-130 在肝癌细胞中具有抗HBV活性。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Perni, R.B., Conway, S.C., Ladner, S.K., et al.Phenylpropenamide derivatives as inhibitors of hepatitis B virus replicationBioorg. Med. Chem. Lett.10(23),2687-2690(2000)
Delaney, W.E., IV, Edwards, R., Colledge, D., et al.Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitroAntimicrob. Agents Chemother.46(9),3057-3060(2002)
Feld, J.J., Colledge, D., Sozzi, V., et al.The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packagingAntiviral Res.76(2),168-177(2007)
