Anhydroerythromycin A
Cat. No.：YN252130
| 产品名称: | Anhydroerythromycin A |
| CAS No.: | 23893-13-2 |
| Chemical Name: | 9-deoxo-6,12-dideoxy-6,9:9,12-diepoxy-erythromycin |
| Synonyms: | 脱水红霉素 |
| 分子量: | 715.91154 |
| 分子式: | C37H65NO12 |
| SMILES: | C[C@@H]1C[C@@]([C@H](O[C@@]2([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@@H](C)[C@H](O[C@@]3([H])C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@H]4C)(C)O[C@]51[C@H](C)[C@@H](O)[C@@](O5)(C)[C@@H](CC)OC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Anhydroerythromycin A 是大环内酯类抗生素红霉素的降解产物。Anhydroerythromycin A 是红霉素在体内外酸性水溶液中降解形成的。Anhydroerythromycin A 在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性 (MIC 分别为12.5 和 6.25 μg/ml)。Anhydroerythromycin A 也抑制人肝微粒体中与细胞色素 P450 (CYP) 亚型 CYP3A 相关的类固醇 6β-羟化酶的活性。 |
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Cachet, T., Van den Mooter, G., Hauchecorne, R., et al.Decomposition kinetics of erythromycin A in acidic aqueous solutionsInt. J. Pharm.55(1),59-65(1989)
Hassanzadeh, A., Helliwell, M., and Barber, J.Determination of the stereochemistry of anhydroerythromycin A, the principal degradation product of the antibiotic erythromycin AOrg. Biomol. Chem.4(6),1014-1019(2006)
Sunazuka, T., Takizawa, H., Desaki, M., et al.Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cellsJ. Antibiot. (Tokyo).52(1),71-74(1999)
Stupans, I., and Sansom, L.N.The inhibition of drug oxidation by anhydroerythromycin, an acid degradation product of erythromycinBiochem. Pharmacol.42(11),2085-2090(1991)
