Hymeglusin
Cat. No.：YN252149
| 产品名称: | Hymeglusin |
| CAS No.: | 29066-42-0 |
| Chemical Name: | 11-[3R-(hydroxymethyl)-4-oxo-2R-oxetanyl]-3,5,7R-trimethyl-2E,4E-undecadienoic acid |
| Synonyms: | F-244; 1233A; L-659699 |
| 分子量: | 324.4 |
| 分子式: | C18H28O5 |
| SMILES: | OC[C@@H](C1=O)[C@H](O1)CCCC[C@@H](C)C/C(C)=C/C(C)=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hymeglusin 作为一种真菌 β-内酯antibiotic，是一种HMG-CoA合酶抑制剂 (IC50= 0.12 μM)。 Hymeglusin 共价修饰酶的活性 Cys129残基。 |
| IC50和靶点: | |
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Greenspan, M.D., Yudkovitz, J.B., Lo, C.Y., et al.Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699Proc. Natl. Acad. Sci. USA84(21),7488-7492(1987)
Tomoda, H., Ohbayashi, N., Morikawa, Y., et al.Binding site for fungal β-lactone hymeglusin on cytosolic 3- hydroxy-3-methylglutaryl coenzyme A synthaseBiochim. Biophys. Acta1636(1),22-28(2004)
Tomoda, H., Ohbayashi, N., Kumagai, H., et al.Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of β-lactone DU-6622Biochem. Bioph. Res. Commun.265(2),536-540(1999)
Balibar, C.J., Shen, X., McGuire, D., et al.cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureusMicrobiology156(Pt 5),1372-1383(2010)
