Zapnometinib
Cat. No.：YN252153
CAS No. ：303175-44-2
| 产品名称: | Zapnometinib |
| CAS No.: | 303175-44-2 |
| Chemical Name: | 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-benzoic acid |
| Synonyms: | PD0184264; ATR-002 |
| 分子量: | 409.5541964 |
| 分子式: | C13H7ClF2INO2 |
| SMILES: | O=C(C1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zapnometinib (PD0184264) 是 CI-1040 的活性代谢物，是一种MEK抑制剂，IC50值为 5.7 nM。Zapnometinib 具有抗流感病毒的抗病毒活性和抗菌活性。 |
| IC50和靶点: | [{name:"MEK:5.7 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Tecle, H., Shao, J., Li, Y., et al.Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?Bioorg. Med. Chem. Lett.19(1),226-229(2009)
Laure, M., Hamza, H., Koch-Heier, J., et al.Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse modelAntiviral Res.178,104806(2020)
