ML-SA1
Cat. No.：YN252157
CAS No. ：332382-54-4
| 产品名称: | ML-SA1 |
| CAS No.: | 332382-54-4 |
| Chemical Name: | 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione |
| Synonyms: | Mucolipin synthetic agonist 1 |
| 分子量: | 362.42176 |
| 分子式: | C22H22N2O3 |
| SMILES: | CC1(C)CC(C)C2=CC=CC=C2N1C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-SA1 作为一种选择性TRPML激动剂，通过促进溶酶体的酸化和蛋白酶活性，抑制登格病毒 2 (DENV2) 和寨卡病毒 (ZIKV)。ML-SA1 抗 DENV2 RNA 和 ZIKV RNA 的IC50值分别为 8.3 μM 和 52.99 μM。ML-SA1 诱发自噬。ML-SA1可用于广谱抗病毒研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shen, D., Wang, X., Li, X., et al.Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium releaseNat. Commun.3,731(2012)
