m-Chloramphenicol
Cat. No.：YN252161
| 产品名称: | m-Chloramphenicol |
| CAS No.: | 37517-28-5 |
| Chemical Name: | O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine |
| Synonyms: | BAY 41-6551 |
| 分子量: | 585.6 |
| 分子式: | C22H43N5O13 |
| SMILES: | NC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](NC([C@@H](O)CCN)=O)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amikacin (BAY 41-6551) 是一种半合成的卡那霉素类似物，对大多数革兰氏阴性菌 (包括庆大霉素和妥布霉素耐药菌株) 都非常有效。Amikacin (BAY 41-6551) 具有耳毒性和肾毒性。 |
| IC50和靶点: | |
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Le Goffic, F., Capmau, M.L., Tangy, F., et al.Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes?J. Antibiot. (Tokyo)33(8),895-899(1980)
Price, K.E., Purisano, T.A., DeFuria, M.D., et al.Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibioticsAntimicrob. Agents Chemother.5(2),143-152(2014)
Georghiou, S.B., Magana, M., Garfein, R.S., et al.Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: A systematic reviewPLoS One7(3),e33275(2012)
Davis, M.A., Baker, K.N.K., Orfe, L.H., et al.Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coliAntimicrob. Agents Chemother.54(6),2666-2669(2010)
