5-Hydroxymethyl-2'-deoxyuridine
Cat. No.：YN252188
| 产品名称: | 5-Hydroxymethyl-2'-deoxyuridine |
| CAS No.: | 5116-24-5 |
| Chemical Name: | α-hydroxy-thymidine |
| Synonyms: | |
| 分子量: | 258.2 |
| 分子式: | C10H14N2O6 |
| SMILES: | O=C(NC(C(CO)=C1)=O)N1[C@H]2C[C@H](O)[C@@H](CO)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Hydroxymethyl-2'-deoxyuridine 是核苷类似物。5-Hydroxymethyl-2'-deoxyuridine 抑制多种人类白血病细胞系的复制IC50值为 1.7-5.8 μM。5-Hydroxymethyl-2'-deoxyuridine 延长了携带 L1210 白血病的小鼠的存活时间。5-Hydroxymethyl-2'-deoxyuridine 可用于细胞复制和白血病的研究。 |
| IC50和靶点: | |
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Shiau, G.T., Schinazi, R.F., Chen, M.S., et al.Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analoguesJ. Med. Chem.23(2),127-133(1980)
Kahilainen, L.I., Berstrom, D.E., and Vilpo, J.A.5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cellsActa. Chem. Scand. B39(6),477-484(1985)
Matsumoto, Y., Rodriguez, V., Whitford, T.A., et al.Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cellsOncoscience2(3),272-284(2015)
Srinivasan, S., and Glauert, H.P.Formation of 5-hydroxymethyl-2'-deoxyuridine in hepatic DNA of rats treated with gamma-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrateCarcinogenesis11(11),2021-2024(1990)
