FC131
Cat. No.：YN252206
| 产品名称: | FC131 |
| CAS No.: | 606968-52-9 |
| Chemical Name: | cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl] |
| Synonyms: | FC 131;cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)，FC-131 |
| 分子量: | 729.8 |
| 分子式: | C36H47N11O6 |
| SMILES: | O=C(NCC(N[C@@H]1CC2=CC=C(O)C=C2)=O)[C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC3=CC(C=CC=C4)=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FC131 是一种有效的CXCR4拮抗剂，可以抑制 [125I]-SDF-1 与CXCR4结合，IC50值为 4.5 nM。FC131 具有抗HIV的活性。 |
| IC50和靶点: | [{name:"125I-SDF-CXCR4:4.5 nM (IC50)'}, 'HIV'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Dorsam, R.T., and Gutkind, J.S.G-protein-coupled receptors and cancerNat. Rev. Cancer7(2),79-94(2007)
Tamamura, H., Hiramatsu, K., Ueda, S., et al.Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131J. Med. Chem.48(2),380-391(2005)
Kuil, J., Buckle, T., and van Leeuwen, F.W.B.Imaging agents for the chemokine receptor 4 (CXCR4)Chem. Soc. Rev.41(15),5239-5261(2012)
