Prostratin
Cat. No.：YN252208
| 产品名称: | Prostratin |
| CAS No.: | 60857-08-1 |
| Chemical Name: | 9a-(acetyloxy)-1,1aR,1bS,4,4aR,7aS,7bR,8R,9,9aS-decahydro-4a,7b-dihydro-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one |
| Synonyms: | 12-Deoxyphorbol-13-acetate |
| 分子量: | 390.5 |
| 分子式: | C22H30O6 |
| SMILES: | OCC1=C[C@H]2[C@H]3[C@@](OC(=O)C)(C[C@@H](C)C2(O)C2C=C(C)C(=O)[C@@]2(O)C1)C3(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prostratin 是一种天然的二萜类物质，为PKC的激活剂，Ki值为 12.5 nM，同时可抑制HIV-1的活性。 |
| IC50和靶点: | [{name:"PKC:12.5 nM (Ki)'}, 'HIV-1'] |
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Bedoya, L.M., Márquez, N., Martínez, N., et al.SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vivoBiochem. Pharmacol.77(6),965-978(2009)
Wender, P.A., Kee, J.M., and Warrington, J.M.Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIVScience320(5876),649-652(2008)
Williams, S.A., Chen, L.F., Kwon, H., et al.Prostratin antagonizes HIV latency by activating NF-ĸBJ. Biol. Chem.279(40),42008-42017(2004)
Biancotto, A., Grivel, J.C., Gondois-Rey, F., et al.Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissueJ. Virol.78(19),10507-10515(2004)
Hezareh, M., Moukil, M.A., Szanto, I., et al.Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: Role of conventional and novel PKC isoformsAntivir. Chem. Chemother.15(4),207-222(2004)
