Fialuridine
Cat. No.：YN252223
CAS No. ：69123-98-4
| 产品名称: | Fialuridine |
| CAS No.: | 69123-98-4 |
| Chemical Name: | 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | FIAU; DRG-0098; NSC 678514 |
| 分子量: | 372.1 |
| 分子式: | C9H10FIN2O5 |
| SMILES: | OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N2C=C(I)C(NC2=O)=O)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fialuridine 是一种具有抗病毒活性的核苷类似物。Fialuridine 具有抗正痘病毒活性。 |
| IC50和靶点: | |
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Mansuri, M.M., Ghazzouli, I., Chen, M.S., et al.1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agentJ. Med. Chem.30(5),867-871(1987)
Colacino, J.M., and Lopez, C.Efficacy and selectivity of some nucleoside analogs as anti-human cytomegalovirus agentsAntimicrob. Agents Chemother.24(4),505-508(1983)
Staschke, K.A., Colacino, J.M., Mabry, T.E., et al.The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-β-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cellAntiviral Res.23(1),45-61(1994)
Watanabe, K.A., Reichman, U., Hirota, K., et al.Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosidesJ. Med. Chem.22(1),21-24(1979)
Attarwala, H.TGN1412: From discovery to disasterJ. Young Pharm.2(3),332-336(2010)
