3′-Azido-2′,3′-dideoxyuridine
Cat. No.：YN252241
CAS No. ：84472-85-5
| 产品名称: | 3′-Azido-2′,3′-dideoxyuridine |
| CAS No.: | 84472-85-5 |
| Chemical Name: | 3′-azido-2′,3′-dideoxy-uridine |
| Synonyms: | AzdU; AzddU; CS-87 |
| 分子量: | 253.21494 |
| 分子式: | C9H11N5O4 |
| SMILES: | O=C1N([C@@]2([H])C[C@@H]([C@H](O2)CO)N=[N+]=[N-])C=CC(N1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3′-Azido-2′,3′-dideoxyuridine (AzdU) 是一种 Zidovudine (HY-17413) 的核苷类似物。3′-Azido-2′,3′-dideoxyuridine 是一种有效的人类免疫缺陷病毒 (HIV) 抑制剂，可抑制HIV在人外周血单个核细胞 (PBMC) 中的复制，对人骨髓细胞 (BMC) 毒性有限。 |
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Balzarini, J., Baba, M., Pauwels, R., et al.Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analoguesBiochem. Pharmacol.37(14),2847-2856(1988)
Eriksson, B.F., Chu, C.K., and Schinazi, R.F.Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphateAntimicrob. Agents Chemother.33(10),1729-1734(1989)
