Depulfavirine
Cat. No.：YN252248
CAS No. ：867365-76-2
| 产品名称: | Depulfavirine |
| CAS No.: | 867365-76-2 |
| Chemical Name: | N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-benzeneacetamide |
| Synonyms: | Ro-0335 |
| 分子量: | 573.2195432 |
| 分子式: | C21H13BrCl2FN3O4S |
| SMILES: | N#CC1=CC(Cl)=CC(OC2=C(F)C(CC(NC3=C(Cl)C=C(S(=O)(N)=O)C=C3)=O)=CC=C2Br)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RO-0335 是一种新型高效的二苯醚非核苷逆转录酶抑制剂(NNTRI)。RO-0335 (IC50= 1.1 nM) 可以抑制WtHIV-1病毒,并且对 92% 的 NNRTI 耐药临床分离株具有保留活性 (IC50<100 nM)。 |
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Javanbakht, H., Ptak, R., G., Chow, E., et al.In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitorAntiviral Res.86(2),212-219(2010)
Supuran, C.T., Nocentini, A., Yakubova, E., et al.Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoformsJ. Enzyme Inhib. Med. Chem.36(1),1056-1060(2021)
