Tenofovir exalidex
Cat. No.：YN252260
CAS No. ：911208-73-6
| 产品名称: | Tenofovir exalidex |
| CAS No.: | 911208-73-6 |
| Chemical Name: | CMX 157; 3-(Hexadecyloxy)propyl Hydrogen ((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate |
| Synonyms: | CMX-157 |
| 分子量: | 569.37 |
| 分子式: | C28H52N5O5P |
| SMILES: | C[C@@H](OCP(O)(OCCCOCCCCCCCCCCCCCCCC)=O)CN1C=NC2=C(N)N=CN=C12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tenofovir exalidex (CMX157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物，对野生型和抗逆转录病毒耐药的HIV毒株，包括多药核苷/核苷酸类似物耐药病毒，都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有HIV-1菌株具有活性，EC50范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性，无明显毒性。Tenofovir exalidex 对HBV |
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Wang, H., et al.: Guoji Yaoxue Yanjiu Zazhi, 43, 134 (2016)
Soriano, V., et al.: Expert Opin. Investig. Drugs, 26, 843 (2017)
